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HomeResearch and OutreachOsler Research Institute for Health InnovationOpen Clinical Trials

Open Clinical Trials

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Ask about how you can participate in our open clinical trials and help pave the way for future advancements. Consider the possibilities and contribute to the health of your community.

TrialActivation statusDisease siteDisease typePhaseBiomarker/pathology
TPX-005-01 (TRIDENT-1) Open All solid tumors Locally advanced or metastatic solid tumor 1/2 ALK or ROS1 positive or NTRK1/2/3 rearrangements
DESTINY LUNG04 (AZ) Open Lung Locally advanced or metastatic NSCLC 3 HER2 mutations in Exon 19 or 20
LAWSON OCELOT Open Lung Advanced NSCLC 2 EGFR activating mutation (excluding exon 20 insertions)
TAS6417-201: Resilient3 Open Lung Advanced NSCLC 2b Exon 20 insertion and uncommon/single or compound epidermal growth factor receptor mutations
TAS6417-301: Resilient3 Open Lung Locally advanced or metastatic non squamous NSCLC 3 EGFR exon 20 insertion
V940-002 Open Lung Resected Stage II, IIIA, IIIB (N2) non-small cell lung cancer 3  
MK-2870-007 Open Lung Non squamous and squamous metastatic NSCLC 3 PD-L1 TPS ≥50%
MK-2870-004 Open Lung Advanced or metastatic non squamous NSCLC 3 EGFR mutations or ALK rearrangements or ROS1 rearrangements or RET rearrangements or BRAF V600E mutation or NTRK fusion or METx14 mutation
M18-868 Open Lung EGFR wild-type advanced/metastatic NSCLC   Non squamous histology only
SGNB6A-002 Open Lung Non-small cell lung cancer with or without actionable genomic alterations 3 Non squamous histology only
JAVELIN MS100070-0119 Open Bladder Locally advanced or metastatic urothelial cancer 2  
MK-3475-365 Opening soon Prostate Metastatic castration resistant prostate cancer 1/2 Adenocarcinoma without small cell histology 
REaCT-HOLD BMA (3CTN) Open Breast and prostate Breast cancer and castrate resistant prostate cancer 4  
MA.40 (FINER) - CCTG Open Breast and prostate Breast cancer and castrate resistant prostate cancer 4  HER2 low ER positive and/or PR positive
Pfizer C4391022 Open Breast Advanced or metastastic breast cancer  3 HR positive and/or HER2 negative
Agendia Flex Open Breast mammaprint testing for stage 1-3 ER positive/Her2   Stage I, II, or III patients who receive MammaPrint, with or without BluePrint testing as standard of care
DYNASTY-Breast02 (Duality) Opening soon Breast Advanced or metastatic breast cancer 3 HER2 low ER positive and/or PR positive
SEAMARK (Pfizer) Open Colorectal Metastatic colorectal cancer 2 BRAF V600E positive MSI-high MMR-deficient
TPX-005-01 (TRIDENT-1) Open All solid tumors Locally advanced or metastatic solid tumor 1/2  ALK or ROS1 positive or NTRK1/2/3 rearrangements 
MK-2140-007 On hold by sponsor Lymphoid Diffuse large B-cell lymphoma 2  
Abbvie M20-621 Open Lymphoid Diffuse large B-cell lymphoma 3 CD20 positive
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